Hanna Niehues, PhD
Future Leaders Symposium
LCE3B/C Deletion – More Than Just a Loss of Two Proteins
Hanna Niehues was born in Germany and moved to The Netherlands in 2007 to study Medical Biology. After her Master’s Degree she started her graduation research at the Experimental Dermatology lab of Prof. Dr. Joost Schalkwijk at the Radboud University Medical Center in Nijmegen in 2012. In 2017 she obtained her PhD degree with Cum Laude distinction and now she follows-up her research on inflammatory skin diseases as a Postdoc at that Department. Hanna’s research is focused on the understanding of genetic risk factors for chronic inflammatory skin diseases like psoriasis and atopic dermatitis. Using organotypic 3D skin models of genotypically defined primary keratinocytes Hanna and colleagues investigate the impact of genetic polymorphisms of keratinocyte-expressed proteins on skin development, morphology and function. Recent studies aim to investigate the cross-talk between keratinocytes and other skin components, like immune cells or skin microbiota to determine how defects in one or more of these compartments can disturb skin balance leading to disease or disease susceptibility.