Robyn Klein, MD/PhD
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Robyn S. Klein, MD/PhD is Professor, Departments of Medicine, Anatomy & Neurobiology, Pathology & Immunology at Washington University School of Medicine St. Louis. She obtained her BA from Barnard College, in 1985. She continued her education at Albert Einstein College of Medicine where she obtained her MD/PhD in Neuroscience in 1993. She did her Residency at Brigham & Women’s Hospital, Boston, MA (1996) followed by a Clinical Fellowship, Infectious Diseases: Massachusetts General Hospital, Boston, MA (1997) and then a Research Fellowship, Infectious Diseases: Massachusetts General Hospital, Boston, MA (2000).
Research in the Klein laboratory focuses on the pathogenesis of neuroinflammatory diseases of the central nervous system (CNS). In particular, we have been interested in the cellular and molecular mechanisms that orchestrate inflammation during both viral and autoimmune encephalitides via endothelial-immune cell interactions. Our studies over the past few years have led us to focus on the roles of cytokines and chemokines in the regulation of blood-brain barrier permeability to protective versus pathogenic leukocytes, and to West Nile virus (WNV), a positive strand flavivirus that may enter the CNS and cause encephalitis. These inflammatory cues also regulate CNS repair by neural stem cells (NSCs) in mice with viral infection or demyelinating diseases. Aspects related to NSC-mediated repair include defining the localizing, proliferative and differentiation cues that lead to successful repair of damaged neurons and myelin.